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Synthetic DNA Created, Evolves on Its Own

☥☽✪☾DAW ☽✪☾ 2012/04/25 00:13:19
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Step aside, DNA—new synthetic compounds called XNAs can also store and copy genetic information, a new study says.

And, in a "big advancement," these artificial compounds can also be made to evolve in the lab, according to study co-author John Chaput of the Biodesign Institute at Arizona State University
Synthetic DNA Created  Evolves on Its Own
Nucleotides, the building blocks of DNA are composed of four bases—A, G, C, and T. Attached to the bases are sugars and phosphates

Synthetic DNA Created  Evolves on Its Own

First, researchers made XNA building blocks to six different genetic systems by replacing the natural sugar component of DNA with one of six different polymers, synthetic chemical compounds.

The team—led by Vitor Pinheiro of the U.K.'s Medical Research Council Laboratory of Molecular Biology—then evolved enzymes, called polymerases, that can make XNA from DNA, and others that can change XNA back into DNA.

Evolution vs. Intelligent Design

This copying and translating ability allowed for genetic sequences to be copied and passed down again and again—artificial heredity.

Last, the team determined that HNA, one of the six XNA polymers, could respond to selective pressure in a test tube.

As would be expected for DNA, the stressed HNA evolved into different forms.

This shows that "beyond heredity, specific XNAs have the capacity for Darwinian evolution," according to the study, published tomorrow in the journal Science

Read Darwin's Legacy

"Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA."
Have you ever heard of The Canadian Holocaust  Vid

XNA Could Demystify Origins of Life?

All of XNA'S actions are "completely controlled by experimentalists—it's 100 percent unnatural," study co-author Chaput noted.

But such control means that scientists can "use [XNA] to ask very basic questions in biology," such as about the origins of life, Chaput said.

For instance, "it's possible that life didn't begin with DNA and proteins like we see today—it may have begun with something much, much simpler," he said.

A scientist could potentially evolve XNA to discover various functions that would have been important for early life.

Overall, he said, the new discovery is "pretty cool—and very powerful.

Oh hai Im DAW

































Read More: http://news.nationalgeographic.com/news/2012/04/12...

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  • Badgerbumface 2012/04/27 19:21:16
  • captainquiggle 2012/04/25 22:44:06
    This is the hopeful dawn of synthetic molecular biology and synthetic genomic...
    captainquiggle
    pretty awesome.
  • oldlady 2012/04/25 12:33:26
    Hail Science!
    oldlady
    Great read, thanks for this information ;)
  • Roberto 2012/04/25 06:17:47
    This is the hopeful dawn of synthetic molecular biology and synthetic genomic...
    Roberto
  • Farnsworth 2012/04/25 05:06:30
    it's life Jim, but not as we know it...
    Farnsworth
    and mankind is messing with stuff that it shouldn't...... but it's damned interesting.
  • Anthony Souls 2012/04/25 04:05:32
    it's life Jim, but not as we know it...
    Anthony Souls
    It's not life, just synthetic storing of preexisting information. Love how there is only options to the views of the poster :P

    "Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]. We also select XNA aptamers, which bind their targets with high affinity and specificity, demonstrating that beyond heredity, specific XNAs have the capacity for Darwinian evolution and folding into defined structures. Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA but are likely to be emergent properties of polymers capable of information storage."

    https://www.sciencemag.org/co...

    1. The synthetic DNA just mimics DNA by creating a structure which can house it, which is based on alternative polymers: They are just storing DNA in different forms; the information is still DNA.

    2. The synthetic DNA "evolves" by them artificially creating the environment for that behavior: this hardl...





    It's not life, just synthetic storing of preexisting information. Love how there is only options to the views of the poster :P

    "Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]. We also select XNA aptamers, which bind their targets with high affinity and specificity, demonstrating that beyond heredity, specific XNAs have the capacity for Darwinian evolution and folding into defined structures. Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA but are likely to be emergent properties of polymers capable of information storage."

    https://www.sciencemag.org/co...

    1. The synthetic DNA just mimics DNA by creating a structure which can house it, which is based on alternative polymers: They are just storing DNA in different forms; the information is still DNA.

    2. The synthetic DNA "evolves" by them artificially creating the environment for that behavior: this hardly confirms evolution of nature. They are simply creating an alternative architecture that can store information that is copied from DNA, and then subjecting that synthetic DNA to circumstances which will allow it to change: seems they are exaggerating their research to fit a desired outcome.

    3. We can already store DNA information in computers, therefore, why does it surprise anyone that, that information can be stored through other organic means? Stored might I add, through the complexity of science, not through natural "evolution". Moreover, trying to link such a creation to the idea that life could "evolve" in such a way on it's own, when such science needed to create such an achievement is akin to the artificiality of computers is absurd to me.

    4. In any event, this does archive one thing, it furthers the understanding of how DNA operates and can be changed through controlled situations.

    Well, I thought I would throw in my two cents. Take care,
    (more)
  • Helmholtz Anthony... 2012/04/25 07:22:05
    Helmholtz
    It's a necessary, even if not sufficient, condition that must be met for evolution's existence to be true. Not sufficient, but still, one more point on science's score card. What's the score again? You guys have, "nobody's ever found Jesus' body" and ten billion animals (times two to seven) fitting on a 450 foot long boat?
  • adhikari_2000 2012/04/25 03:13:18
    it's life Jim, but not as we know it...
    adhikari_2000
    Dear Friends, These DNA possibly left-handed, whereas Si life is right handed but our nature with its privilege of four forces cannot confirm very withstanding landscape of interventional or non-interventional creation with the very fate of all forces for symmetry breaking and symmetry cannot confirm for randomness or break of randomness. So it is intelligent design mixing our biological world of various accidents of pro-life with universality of mind to read, write and copy of synthetic forms with seeing the very rhythm what we biologically know means of evolution where everything attacks like parasite seek individuality when life search for taking shelter in extreme hot or cold with uncertainty for more or less precision, Oh! The elegant universe!Thank you all. Virgin Mary blesses America.
    Magnetic field of the monopole penetrates radially into the bulk chiral superconductor along the lines of the l̂ vector field. Nexus insurrection of monopole quantized topology not exonerate dirac string(absorbed and radial flux of dirac string)
    Dear Friends, These DNA possibly left-handed, whereas Si life is right handed but our nature with its privilege of four forces cannot confirm very withstanding landscape of interventional or non-interventional creation with the very fate of all forces for symmetry breaking and symmetry cannot confirm for randomness or break of randomness. So it is intelligent design mixing our biological world of various accidents of pro-life with universality of mind to read, write and copy of synthetic forms with seeing the very rhythm what we biologically know means of evolution where everything attacks like parasite seek individuality when life search for taking shelter in extreme hot or cold with uncertainty for more or less precision, Oh! The elegant universe!Thank you all. Virgin Mary blesses America. leonard susskind feynman B Greene t hooft modification of feynman diagram monopoles in superconductors
    Magnetic field of the monopole penetrates radially into the bulk chiral superconductor along the lines of the l̂ vector field. Nexus insurrection of monopole quantized topology not exonerate dirac string(absorbed and radial flux of dirac string)
    Stephen Hawking Roger Penrose
    (more)
  • ☥☽✪☾DAW... adhikar... 2012/04/25 03:23:29 (edited)
    ☥☽✪☾DAW ☽✪☾
    Scientists hmmmmmmmmmmm
    scientists sexy scientists sexy scientists sexy
  • adhikar... ☥☽✪☾DAW... 2012/04/25 03:30:05
    adhikari_2000
    It is a great mistake for men to give up paying compliments, for when they give up saying what is charming, they give up thinking what is charming. Thank you. God's blessing.
  • Christopher Brady 2012/04/25 03:01:20
    it's life Jim, but not as we know it...
    Christopher Brady
  • bob h. 2012/04/25 02:37:17
    Hail Science!
    bob h.
    +2
    As pure science, great. But a use for it?
  • ☥☽✪☾DAW... bob h. 2012/04/25 03:02:04
    ☥☽✪☾DAW ☽✪☾
    +1
    they can use this science to cure all diseases Genetic and rewrite virus dna to attack other viruses like use Cancer Cells to Attack and Destroy HIV and cure Genetic Diseases and many other problems
  • Tomus Megalomania 2012/04/25 02:09:29
    Hail Science!
    Tomus Megalomania
    +1
    I don't really understand the application or advance here.
  • ☥☽✪☾DAW... Tomus M... 2012/04/25 02:15:06 (edited)
    ☥☽✪☾DAW ☽✪☾
    +4
    they just proved the Theory of Evolution by Creating artificial DNA and it evolved

    they can use this science to cure all diseases Genetic and rewrite virus dna to attack other viruses like use Cancer Cells to Attack and Destroy HIV and cure Genetic Diseases and many other problems
  • Tomus M... ☥☽✪☾DAW... 2012/04/25 02:19:34
    Tomus Megalomania
    +2
    That would be amazing. I hope it is one step closer to those advances.
  • Anthony... ☥☽✪☾DAW... 2012/04/25 04:04:07
    Anthony Souls
    "Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]. We also select XNA aptamers, which bind their targets with high affinity and specificity, demonstrating that beyond heredity, specific XNAs have the capacity for Darwinian evolution and folding into defined structures. Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA but are likely to be emergent properties of polymers capable of information storage."

    https://www.sciencemag.org/co...

    1. The synthetic DNA just mimics DNA by creating a structure which can house it, which is based on alternative polymers: They are just storing DNA in different forms; the information is still DNA.

    2. The synthetic DNA "evolves" by them artificially creating the environment for that behavior: this hardly confirms evolution of nature. They are simply creating an alternative architecture that can store information that is copied from DN...





    "Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]. We also select XNA aptamers, which bind their targets with high affinity and specificity, demonstrating that beyond heredity, specific XNAs have the capacity for Darwinian evolution and folding into defined structures. Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA but are likely to be emergent properties of polymers capable of information storage."

    https://www.sciencemag.org/co...

    1. The synthetic DNA just mimics DNA by creating a structure which can house it, which is based on alternative polymers: They are just storing DNA in different forms; the information is still DNA.

    2. The synthetic DNA "evolves" by them artificially creating the environment for that behavior: this hardly confirms evolution of nature. They are simply creating an alternative architecture that can store information that is copied from DNA, and then subjecting that synthetic DNA to circumstances which will allow it to change: seems they are exaggerating their research to fit a desired outcome.

    3. We can already store DNA information in computers, therefore, why does it surprise anyone that, that information can be stored through other organic means? Stored might I add, through the complexity of science, not through natural "evolution". Moreover, trying to link such a creation to the idea that life could "evolve" in such a way on it's own, when such science needed to create such an achievement is akin to the artificiality of computers is absurd to me.

    4. In any event, this does archive one thing, it furthers the understanding of how DNA operates and can be changed through controlled situations.

    Well, I thought I would throw in my two cents. Take care,
    (more)
  • ☥☽✪☾DAW... Anthony... 2012/04/25 12:36:39
    ☥☽✪☾DAW ☽✪☾
    +1
    your not a Scientist so i dont care what you think
  • D.C. Willis 2012/04/25 01:14:10
    I thought we evolved from microbs left behind by spacecraft that visited this...
    D.C. Willis
  • Joel Buccellato 2012/04/25 01:10:39
    This is the hopeful dawn of synthetic molecular biology and synthetic genomic...
    Joel	 Buccellato
    +1
    I can see this as a possible cure for genetic defects and even cancer
  • Caedus01 Sith Lord of the P... 2012/04/25 00:53:34
    it's life Jim, but not as we know it...
    Caedus01 Sith Lord of the PHAET
    +1
    I see the MAtrix happening REAL soon
  • Razoreye001 2012/04/25 00:44:35
    Hail Science!
    Razoreye001
    +3
    god is imaginary this is real.
  • holyheretic 2012/04/25 00:36:02
  • Midnite12 2012/04/25 00:29:19
    .All this experiment is doing is artificially simulating patterns that are al...
    Midnite12
    +1
    Oh hell, I don't know! :/
  • Andy Fletcher 2012/04/25 00:28:01
    it's life Jim, but not as we know it...
    Andy Fletcher
    +2
    We have to be extremely careful of the journeys we embark upon. This could be a very good thing, or a very bad thing, depending on what we do with it.
  • Kirino 2012/04/25 00:24:34 (edited)
  • Earthly Resident 2012/04/25 00:21:28
    Hail Science!
    Earthly Resident
    +4
    i am definitely gonna do some more research on that, nvr heard of XNA before!!
  • ☥☽✪☾DAW... Earthly... 2012/04/25 00:25:24
  • Earthly... ☥☽✪☾DAW... 2012/04/25 00:29:48
    Earthly Resident
    +3
    thx bro!! :))

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